The patient can therefore choose the particular drug that they find works best, or the formulation (tablet size) that suits them.
For paediatric suspensions, the choice may be determined by a preferred flavour.
This is less of a problem with newer ‘second generation’ antihistamines, such as loratadine, and ‘third generation’ antihistamines such as desloratadine.
Oral antihistamines also have the benefit of treating associated conjunctival symptoms.However, pregnant women must be warned about the other aspects of safety such as sedation and consider whether they should not drive while taking these drugs.The newer antihistamines are likely to be as safe in pregnancy but have not been used by as many women, so they do not have the same evidence of safety.There is now little role for sedating antihistamines in allergic conditions.Less sedating antihistamines are equally efficacious. The less sedating antihistamines can be taken long term with no loss of efficacy, and an ongoing good safety profile.